Estupinan, 27, made 104 appearances for Brighton after joining the Premier League club from Villarreal in 2022. He will now be part of a Milan side that aims to improve its performance in the Serie A league.
Former manager Massimiliano Allegri has returned to the club for a second spell, and the team has also signed former Real Madrid midfielder Luka Modric. Brighton's coach, Fabian Hurzeler, expressed his gratitude to Estupinan for his contributions to the club.
Estupinan is now looking forward to a new challenge in Serie A, and Brighton wishes him the best for the future.