Isak played the full 90 minutes in Newcastle's 1-0 loss to Everton on the final day of the Premier League season, but struggled to make an impact in the game.
He had also been sidelined with the same injury in Newcastle's previous match against Arsenal, suggesting that it may have affected his performance in the Everton game.
As a result, Isak has been forced to withdraw from Sweden's upcoming international friendlies against Hungary and Algeria in June, missing out on the opportunity to add to his 16 goals and 52 caps for his country.
Sweden's manager, Jon Dahl Tomasson, will be without a full-strength attack for the second international window in a row, as Viktor Gyokeres was also unavailable for the previous friendlies in March.
To compensate for the loss of Isak, Tomasson has called up Jordan Larsson from FC Copenhagen and Gustaf Nilsson from Club Brugge to join the squad.
The June friendlies will be an important opportunity for Tomasson to experiment with his team before World Cup qualification begins in September.
Sweden will face Hungary on June 6th and Algeria on June 10th, and fans can stay updated with the latest news and scores on Flashscore.