The negotiations between Arsenal and Sevilla are taking place alongside talks about a new contract for Thomas Partey, who is set to leave the club at the end of June.
Agoume is being considered as a potential replacement for Partey, and the 23-year-old has shown impressive form in his previous season with Sevilla.
Although Martin Zubimendi is set to join Arsenal from Real Sociedad, the club is still looking to add another midfielder, and Agoume is emerging as their main target.